Endocrine Abstracts

Introduction: Hyalinizing trabecular adenomas (HTA) of the thyroid gland is a rare neoplasm of follicular cell origin. HTA can be present as a thyroid nodule or incidental finding in a thyroidectomy specimen. HTA is generally accepted to be a benign tumor, but their cytological features can be similar to those of papillary thyroid carcinoma (PTC).Case report: A 59 year old woman, who had cholangiocellular carcinoma, admitted to our institution with a sol...

Aim: Delayed gastric emptying affects a substantial proportion of patients with long-standing diabetes. On the other hand changes in gastric incretin hormones also play an important role in the pathophysiology of diabetes. In our study, we aimed to investigate the incidence of gastrointestinal disease in patients with newly diagnosed diabetes and pre-diabetes.Methods: A total of 73 patients with newly diagnosed pre-diabetes and diabetes were included in ...

Aim: Metformin is usually well-tolerated and commonly used oral-antidiabetic in type-2 diabetes and pre-diabetes. The most common side effects are gastrointestinal (GI) ones. It is proposed that, extended-release form of metformin has less gastrointestinal side effects. We aimed to compare the extended-release and normal-release form metformin in type-2 diabetic and prediabetic patients for gastrointestinal tolerability, weight effect and glycemic control.<p class="abstext...

5-Alpha reductase deficiency is a rare 46, XY disorder of sex differentation caused by mutations in the 5-alpha reductase type 2 gene (SRD5A2) located on chromosome 2p23. Affected patients have a deficiency of the 5-alpha reductase type 2 enzyme, which becomes partially or totally unable to convert testosterone into dihydrotestosterone, the latter being responsible for the development of the external genitalia, prostate, and urethra in the male fetus. Most affected individuals...

Introduction: SGLT2 inhibitors have been an important step in the treatment of diabetes. With numerous controlled experimental studies of these antidiabetic drugs, evaluation of real-life data after entry into clinical practice is an important condition. In our study, it was aimed to evaluate short-term results on glycemic control and weight loss in a narrow group of patients in the single tertiary medical center.Methods: The study was retrospectively de...

Introduction: Polycystic ovary syndrome (PCOS) is a common, multifaceted endocrinopathy associated with metabolic alterations such as insulin resistance, hyperinsulinemia, dyslipidemia, and obesity, and thereby an increased risk of developing type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Endothelial dysfunction and chronic inflammation are early findings in the atherosclerotic process. Elevated serum levels of uric acid may reflect low-grade chronic inflamm...

Background: The polycystic ovary syndrome (PCOS) is often seen in reproductive age women. Although the ratio of insulin resistance is not knowm definitely in PCOS patients it is thought to be between 50 to 65%. Several studies have shown that low serum 25-Hydroxy Vitamin D (25(OH) D) levels are associated with high body mass index (BMI), insulin resistance, and waist/hip circumference, but it has not yet been clearly determined. In this study, we aimed to determine the correla...

Introduction: The aim of this study is to investigate association between Hashimoto’s thyroiditis (HT) and vestibular function and the possible effect of levothyroxine (LT4) treatment on vestibular functionPatients and methods: We recruited 61 patients with HT and 30 age and gender matched healthy individuals for the study. Of 30 patients with HT were on LT4 treatment (group I) and 31 patients were treatment naive (group II). None of the patients ha...

Background: Antiphospholipid syndrome (APS) is characterized by venous or arterial thrombosis and/or an adverse pregnancy outcome in the presence of persistent laboratory evidence of antiphospholipid antibodies. Loss of adrenal function due to bilateral adrenal vein thrombosis, resulting in hemorrhagic infarction, may occur in association with APS.Case presentation: We present the case of a 45-year-old woman with APS diagnosis since she was 37, with hist...

Primary Hyperparathyroidism is a common endocrine disorder characterized with high parathyroid hormone (PTH) and calcium (Ca) levels. Although most of the patients are asymptomatic, some patients may be presented with renal, gastrointestinal, musculoskeletal, neurologic or cardiovascular signs associated with hypercalcemia or elevated parathyroid hormone related findings such as bone disease, nephrolithiasis, hypophosphatemia increased production of calcitriol, hypomagnesemia,...